Nishad Matange

This study shows that engineering FAD biosynthesis in E. coli to produce nucleotide analogues increases tolerance to aminoglycoside antibiotics by altering metabolic pathways.

This study compares the adaptation of E. coli and K. aerogenes to antibiotics, finding that their differing genotype-phenotype maps determine their capacity to evolve resistance.

The paper shows that proteostasis influences gene dosage evolution in antibiotic-resistant bacteria by modulating DHFR expression and copy number changes under trimethoprim pressure.