The biosynthesis of FAD nucleotide analogues in Escherichia coli alters its sensitivity to aminoglycoside antibiotics
Ateek Shah, Shreya Mahato, Prathith Bhargav, Reman Kumar Singh, Yashwant Kumar, Pratishruti Panda, Janhavi Borkar, Lavisha Parab, Nishad Matange, Arnab Mukherjee, Amrita Brajagopal Hazra
This study shows that engineering FAD biosynthesis in E. coli to produce nucleotide analogues increases tolerance to aminoglycoside antibiotics by altering metabolic pathways.
ACS Synthetic Biology · Oct 28, 2026Peer-reviewedMicrobiology