Author

Leili Zhang

IBM Research - Thomas J. Watson Research CenterORCID 0000-0002-2952-4858Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Chih-Chieh YangiD· 1 shared Christina GaughaniD· 1 shared Claudia Marcela Diaz-MonteroiD· 1 shared Efrat HexteriD· 1 shared Giacomo DomeniconiiD· 1 shared Gyanu ParajuliiD· 1 shared Ivan JurićiD· 1 shared Jeffrey A. KnaufiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBioinformatics

Chih-Chieh YangORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Engineering Endogenous T Cell Receptors to Recognize Cancer Neoantigens Using a Hybrid Physics-AI Approach

Jeffrey K. Weber, Gyanu Parajuli, S H Wang, Vadim Ratner, Xiaoxiao Ma, Yoel Shoshan, Leili Zhang, Joseph A. Morrone, Moshiko Raboh, Efrat Hexter, Prerana Bangalore Parthasarathy, Paul G. Pavicic, Christina Gaughan, Vladimir Makarov, Lawrence Chu, , Timothy An-thy Chan

The paper uses a hybrid physics-AI approach to engineer functional TCRs targeting cancer neoantigens, showing improved efficacy compared to patient-derived TCRs.

bioRxiv · May 19, 2026 · PreprintImmunology

On Correlation between Structural Properties and Viral Escape Measurements from Deep Mutational Scanning

Leili Zhang, Giacomo Domeniconi, Chih-Chieh Yang

The paper correlates structural properties with viral escape measurements using deep mutational scanning and finds high correlation coefficients with improved results using simulations and random forest models.

bioRxiv · Feb 17, 2022 · PreprintBioinformatics