Timothy An-thy Chan

MCL1 may not mediate chemoresistance

This study challenges the role of MCL1 in chemoresistance by showing no evidence of nuclear accumulation or DNA repair interactions in live cancer cells.

Platelets regulate glioblastoma growth and immunity via sex-dependent PAR4 - Estrogen receptor beta signaling

This study shows that platelet PAR4 signaling, interacting with estrogen receptor beta, drives glioblastoma progression and immune suppression, with sex-specific effects on survival and TME dynamics.

Quantum Convolutional HLA Immunogenic Peptide Prediction (Q-CHIPP): Next-Generation Neoantigen Prediction with Quantum Neural Networks

This paper introduces Q-CHIPP, a quantum neural network for predicting HLA immunogenic peptides, combining MHC binding and immunogenicity prediction using quantum hardware.

Inhibition of KDEL receptors remodels the tumor microenvironment for robust T cell independent tumor regression

The paper shows that inhibiting KDELR2 in tumor cells promotes tumor regression through innate immune activation, independent of T cells, and primes anti-tumor T cells for future challenges.

Engineering Endogenous T Cell Receptors to Recognize Cancer Neoantigens Using a Hybrid Physics-AI Approach

The paper uses a hybrid physics-AI approach to engineer functional TCRs targeting cancer neoantigens, showing improved efficacy compared to patient-derived TCRs.

Neural cell state modulation by PARK2 and dopaminergic neuroprotection by small molecule Parkin agonism

This study shows that Parkin is essential for neuronal differentiation and survival, and small molecule Parkin agonists like FB231 protect dopaminergic neurons in Parkinson's disease models.

Single Cell RNA-sequencing of BCG naive and recurrent non-muscle invasive bladder cancer reveals a CD6/ALCAM mediated immune-suppressive pathway

This study uses single-cell RNA sequencing to identify a CD6/ALCAM-mediated immune-suppressive pathway in recurrent NMIBC, suggesting CD6 as a potential therapeutic target.

Resource-efficient pooled sequencing expands translational impact in solid tumors

This paper introduces a pooled sequencing strategy to address intratumoral genetic heterogeneity in cancer, showing it improves mutation detection and risk stratification while reducing costs.

Multimodal Single-Cell Omics Analysis of COVID-19 Sex Differences in Human Immune Systems

The paper examines sex differences in COVID-19 outcomes and immune responses using single-cell RNA-sequencing and clinical data, finding higher risk for males and potential mechanisms for sex-specific treatments.