Engineering Endogenous T Cell Receptors to Recognize Cancer Neoantigens Using a Hybrid Physics-AI Approach
Jeffrey K. Weber, Gyanu Parajuli, S H Wang, Vadim Ratner, Xiaoxiao Ma, Yoel Shoshan, Leili Zhang, Joseph A. Morrone, Moshiko Raboh, Efrat Hexter, Prerana Bangalore Parthasarathy, Paul G. Pavicic, Christina Gaughan, Vladimir Makarov, Lawrence Chu, , Timothy An-thy Chan
The paper uses a hybrid physics-AI approach to engineer functional TCRs targeting cancer neoantigens, showing improved efficacy compared to patient-derived TCRs.
bioRxiv · May 19, 2026 · PreprintImmunology