Author

Jon-Michael T. Beasley

University of North Carolina at Chapel HillORCID 0000-0002-2957-8792Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Bioinformatics· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 2 Organism:human· 1 Approach:large language model· 1 Approach:machine learning (classical)· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexander TropshaiD· 2 shared Eugene N. MuratoviD· 2 shared Alexey V. ZakharoviD· 1 shared Anton SimeonoviD· 1 shared Daniel James CronaiD· 1 shared Dorjbal G. Dorjsuren· 1 shared Elvin Ding· 1 shared Kara SchatziD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBioinformatics

Alexander TropshaORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

TARRAGON: Therapeutic Target Applicability Ranking and Retrieval-Augmented Generation Over Networks

Jon-Michael T. Beasley, Kara Schatz, Elvin Ding, Marcello DeLuca, Nahed Abu Zaid, Nyssa Tucker, Rada Y. Chirkova, Daniel James Crona, Alexander Tropsha, Eugene N. Muratov

TARRAGON prioritizes and validates therapeutic targets for non-muscle invasive urinary bladder cancer using a computational framework integrating knowledge graphs and large language models.

bioRxiv · Apr 19, 2025 · PreprintBioinformatics

Breaking the Phalanx: Overcoming Bacterial Drug Resistance with Quorum Sensing Inhibitors that Enhance Therapeutic Activity of Antibiotics

Jon-Michael T. Beasley, Dorjbal G. Dorjsuren, Sankalp Jain, Marielle K. Rath, Ricardo Scheufen Tieghi, Alexander Tropsha, Anton Simeonov, Alexey V. Zakharov, Eugene N. Muratov

This study identifies synergistic combinations of quorum-sensing inhibitors and antibiotics to combat antibiotic-resistant bacteria, finding that piperacillin with ketoprofen, indomethacin, and piroxicam shows broad antimicrobial action.

bioRxiv · Jan 17, 2025 · PreprintBioinformatics