Sankalp Jain

This paper identifies broad-spectrum filovirus inhibitors using computational screening and validates them against multiple viral species, finding synergistic compound pairs effective against Ebola and Marburg viruses.

SCOPE identifies molecular mechanisms in phenotypic screens by linking compound data to pathways and targets, revealing calcium signaling and HRH1 as key in exodosis regulation.

This study identifies synergistic combinations of quorum-sensing inhibitors and antibiotics to combat antibiotic-resistant bacteria, finding that piperacillin with ketoprofen, indomethacin, and piroxicam shows broad antimicrobial action.

The paper develops an AI-cell model using a transformer architecture to predict interferon production by monocytes in response to nucleic acid nanoparticles.

The paper identifies five compounds that inhibit SARS-CoV-2 replication by binding to ACE2 without disrupting its enzymatic function, serving as potential acute treatments for COVID-19.

This study identifies novel TMPRSS2 inhibitors through virtual screening and experimental validation, offering potential drug candidates for COVID-19 treatment.