Alexey V. Zakharov

This paper identifies broad-spectrum filovirus inhibitors using computational screening and validates them against multiple viral species, finding synergistic compound pairs effective against Ebola and Marburg viruses.

This study identifies synergistic combinations of quorum-sensing inhibitors and antibiotics to combat antibiotic-resistant bacteria, finding that piperacillin with ketoprofen, indomethacin, and piroxicam shows broad antimicrobial action.

The paper develops an AI-cell model using a transformer architecture to predict interferon production by monocytes in response to nucleic acid nanoparticles.

The paper curates a database of antiviral compounds tested against 13 emerging viruses, identifies potential broad-spectrum antivirals, and highlights the need for coordinated research efforts.

The paper identifies five compounds that inhibit SARS-CoV-2 replication by binding to ACE2 without disrupting its enzymatic function, serving as potential acute treatments for COVID-19.