Author

Paco López‐Cuevas

University of BristolORCID 0000-0002-2963-6438Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein design· 1 Research Focus:software / tool· 1 Organism:zebrafish· 1

Frequent Co-Authors

Alastair SmithiD· 1 shared Chrissy L. HammondiD· 1 shared Elisa K. Barrow MolinaiD· 1 shared Érika KagueiD· 1 shared Jim R. HughesiD· 1 shared Luke DeaneiD· 1 shared Matthew NichollsiD· 1 shared Richard Mark WhiteiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperSynthetic Biology

Alastair SmithORCID

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2 papers

Recent·Most cited

TRANCERs: Engineering enhancers into autonomous tissue-specific expression cassettes

Elisa K. Barrow Molina, Alastair Smith, Paco López‐Cuevas, Matthew Nicholls, Sumana Sharma, Richard Mark White, Thomas A. Milne, Jim R. Hughes

TRANCERs convert enhancers into autonomous tissue-specific promoters, enabling precise and programmable gene expression for research and therapy.

bioRxiv · Oct 27, 2025 · PreprintSynthetic Biology

Transformed notochordal cells trigger chronic wounds destabilizing the vertebral column and bone homeostasis

Paco López‐Cuevas, Luke Deane, Yushi Yang, Chrissy L. Hammond, Érika Kague

The paper shows transformed notochordal cells in zebrafish cause skeletal damage, chronic wound-like responses, and bone homeostasis disruption, linking chordomas to inflammation and IVD degeneration.

Disease Models & Mechanisms · Feb 12, 2021Peer-reviewedDevelopmental Biology