Micah A. Luftig

Dissecting Epstein-Barr Virus Dependence Across Diverse Infected Cell Models

The paper assesses EBV dependence in various infected cell models and finds that EBV loss sensitivity varies across cell types, with lymphoid malignancies being more dependent than gastric adenocarcinoma lines.

HIV-associated non-Hodgkin lymphoma tumor-microenvironment axes differ by EBV status across cellular origins

This study uses spatial transcriptomics to show that EBV+ HIV-associated NHLs have distinct tumor microenvironment features, including immunosuppressive pathways and spatial organization similar to lymphoid tissues.

Single-Cell Profiling of HDAC Inhibitor-Induced EBV Lytic Heterogeneity Defines Abortive and Refractory States in B Lymphoblasts

This study uses single-cell RNA sequencing to analyze the effects of HDAC inhibitors on EBV lytic reactivation in B lymphoblasts, identifying abortive and refractory states.

Sp140L Is a Novel Herpesvirus Restriction Factor

The paper identifies Sp140L as a novel restriction factor that herpesviruses counteract to evade innate immune responses and establish infection.

Fatty acid desaturases link cell metabolism pathways to promote proliferation of Epstein-Barr virus-infected B cells

This study identifies fatty acid desaturases SCD1 and FADS2 as critical for EBV-induced B cell proliferation and reveals their role in promoting metabolic pathways that support lymphoma growth.

Human genetic variation reveals FCRL3 is a lymphocyte receptor for Yersinia pestis

The paper identifies FCRL3 as a receptor for Yersinia pestis using a genome-wide association study and shows a variant in FCRL3 is linked to both plague susceptibility and hepatitis C risk.

Epstein-Barr virus reactivation induces divergent abortive, reprogrammed, and host shutoff states by lytic progression

This study uses single-cell transcriptomics to analyze EBV lytic reactivation in B cells, revealing abortive, reprogrammed, and host shutoff states with distinct gene expression patterns.

Incorporation of Epstein-Barr viral variation implicates significance of LMP1 in survival prediction and prognostic subgrouping in Burkitt lymphoma

The paper identifies EBV variants, particularly in LMP1, associated with survival in Burkitt lymphoma and defines prognostic subgroups based on these features.

Epstein Barr virus genomes reveal population structure and type 1 association with endemic Burkitt lymphoma

The paper analyzes EBV genomes from eBL patients and controls in Kenya, finding type 1 EBV is more common in patients and identifying genetic variants associated with eBL.