Author

Luis Roberto Cassinotti

University of MichiganORCID 0000-0002-2965-6826Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1

Frequent Co-Authors

Gabriel CorfasiD· 3 shared Lingchao JiiD· 3 shared Aditi S. DesaiiD· 2 shared Nathan D. CassiD· 2 shared Andrew Wylie· 1 shared Beatriz C. BorgesiD· 1 shared Charles BurantiD· 1 shared Costas Andreas LyssiotisiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersNeuroscience

Gabriel CorfasORCID

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4 papers

Recent·Most cited

Retinoic acid signaling guides the efficiency of inner ear organoid-genesis and governs sensory-nonsensory fate specification

Robert Keith Duncan, Liqian Liu, Mo Moyer, Andrew Wylie, Ranya Dano, Luis Roberto Cassinotti

The paper identifies retinoic acid signaling's role in inner ear organoid development, showing it affects organoid efficiency and sensory-nonsensory fate specification.

Stem Cell Reports · Oct 1, 2025Peer-reviewedNeuroscience

Lipidomics profiling identifies β-oxidation as a key process in noise-induced hearing loss

Gunseli Wallace, Lingchao Ji, Luis Roberto Cassinotti, Maureen T. Kachman, Costas Andreas Lyssiotis, Charles Burant, Gabriel Corfas

The paper identifies β-oxidation as a key process in noise-induced hearing loss using lipidomics profiling and validates it with Etomoxir treatment.

bioRxiv · Mar 25, 2025 · PreprintNeuroscience

Hidden hearing loss in a Charcot-Marie-Tooth type 1A mouse model

Luis Roberto Cassinotti, Lingchao Ji, Mary Caroline Yuk, Aditi S. Desai, Nathan D. Cass, Zahara A. Amir, Gabriel Corfas

This study shows that mild auditory nerve myelination defects in CMT1A mice cause hidden hearing loss, suggesting a link between peripheral neuropathies and auditory issues.

JCI Insight · Aug 23, 2024Peer-reviewedNeuroscience

Cochlear Neurotrophin-3 overexpression at mid-life prevents age-related cochlear synaptopathy and slows age-related hearing loss

Luis Roberto Cassinotti, Lingchao Ji, Beatriz C. Borges, Nathan D. Cass, Aditi S. Desai, David C. Kohrman, M. Charles Liberman, Gabriel Corfas

This study shows that overexpressing neurotrophin-3 in middle-aged mice prevents age-related cochlear synaptopathy and slows hearing loss.

bioRxiv · Apr 5, 2022 · PreprintNeuroscience