M. Charles Liberman

Lack of Oncomodulin Increases ATP-Dependent Calcium Signaling and Susceptibility to Noise in Adult Mice

This study shows that lack of oncomodulin in adult mice increases ATP-dependent calcium signaling and susceptibility to noise-induced hearing loss.

Physiological, Histological, and Cognitive Characterization of a Macaque Model of Presbycusis

This study characterizes age-related hearing loss in rhesus macaques through histological, physiological, and cognitive assessments, finding correlations between auditory deficits and cognitive impairments.

Cochlear histopathology in macaques after noise-induced temporary threshold shifts

This study examines cochlear histopathology in macaques after noise-induced temporary threshold shifts, finding no significant loss of hair cells or synapses but chronic ribbon enlargement.

A modiolar-pillar gradient in auditory-nerve dendritic length: a novel post-synaptic contribution to dynamic range?

The paper identifies a modiolar-pillar gradient in auditory-nerve dendritic length in guinea pigs, suggesting it contributes to differences in threshold sensitivity among auditory-nerve fibers.

Large-scale annotated dataset for cochlear hair cell detection and classification

The paper presents a large annotated dataset of cochlear hair cells for machine learning applications in hearing research.

Supporting-cell vs. hair-cell survival in the human cochlea: Implications for regenerative therapies

The paper assesses supporting-cell survival in human cochleas and finds it correlates with audiogram slope and ototoxic hearing loss.

Inner hair cell synapse density influences auditory processing

This study shows that changes in inner hair cell synapse density affect auditory temporal processing but not reflexes, suggesting a therapeutic approach for hearing loss.

Cochlear Neurotrophin-3 overexpression at mid-life prevents age-related cochlear synaptopathy and slows age-related hearing loss

This study shows that overexpressing neurotrophin-3 in middle-aged mice prevents age-related cochlear synaptopathy and slows hearing loss.

Probing adaptation and spontaneous firing in human auditory-nerve fibers with far-field peri-stimulus time responses

The paper uses PSTR to predict adaptation and spontaneous firing rates in human auditory nerve fibers, showing agreement with single-unit recordings in animals.

Effects of cochlear synaptopathy on spontaneous and sound-evoked activity in the mouse inferior colliculus

This study investigates how cochlear synaptopathy affects spontaneous and sound-evoked activity in the mouse inferior colliculus, finding no change in spontaneous rates but altered sound-evoked responses.