Druggability of Phospholipase C-β Isoforms with Small Peptides Patterned after the Autoinhibitory XY Linker
Jorge de Andrés-López, David Cabañero, Isabel Devesa, Shihab S. Shah, Gregorio J. Fernandez-Ballester, Nikita L. Gamper, M. Ángeles Bonache, Rosario González‐Muñiz, Asia M. Fernández-Carvajal, Antonio Vicente Ferrer-Montiel
The paper identifies peptides based on the autoinhibitory XY linker of PLCβ isoforms that inhibit PLCβ activity and reduce inflammation and pain in a mouse model.
bioRxiv · Jul 22, 2025 · PreprintMolecular Biology