Molecular BiologybioRxivPreprint
Engineering Nme2Cas9 Adenine Base Editors with Improved Activity and Targeting Scope
Nathan Bamidele, Han Zhang, Xiaolong Dong…·Erik J. Sontheimer
This paper engineers Nme2Cas9 base editors to improve activity and targeting scope, enabling correction of MECP2 mutations with minimal off-target effects.
DOI 10.1101/2023.04.14.536905