Variant characterization in the intrinsically disordered human proteome
Dalmira Hubrich, Jesús Alvarado-Valverde, Chop Yan Lee, Milena Djokic, Mareen Welzel, Kristina Hintz, Joelle Morgan Strom, Katja Luck
The paper improves variant effect prediction in intrinsically disordered regions by combining sequence analysis, AlphaFold, and experiments to annotate protein interactions and predict deleterious variants.
Nature Structural & Molecular Biology · Jul 31, 2026Peer-reviewedSystems Biology