Dalmira Hubrich

Variant characterization in the intrinsically disordered human proteome

The paper improves variant effect prediction in intrinsically disordered regions by combining sequence analysis, AlphaFold, and experiments to annotate protein interactions and predict deleterious variants.

Systematic discovery of protein interaction interfaces using AlphaFold and experimental validation

The paper evaluates AlphaFold-Multimer for predicting protein interaction interfaces using short linear motifs and validates some predictions experimentally.

Binding of single-mutant epidermal growth factor (EGF) ligands alter the stability of the EGF receptor dimer and promote growth signaling

This study shows that single-mutant EGF ligands alter EGFR dimer stability and signaling, supporting biased signaling theory.