Joelle Morgan Strom

Foldseek-Interface clusters protein interaction interfaces from PDB data, revealing 77,167 interface clusters and novel interface types.

The paper improves variant effect prediction in intrinsically disordered regions by combining sequence analysis, AlphaFold, and experiments to annotate protein interactions and predict deleterious variants.

The paper evaluates AlphaFold-Multimer for predicting protein interaction interfaces using short linear motifs and validates some predictions experimentally.