Mareen Welzel

Cellular context defines brain-specific functions of genes associated with neurodevelopmental disorders

The paper identifies brain-specific functions of NDD-associated genes by analyzing gene expression and regulatory mechanisms across tissues.

Variant characterization in the intrinsically disordered human proteome

The paper improves variant effect prediction in intrinsically disordered regions by combining sequence analysis, AlphaFold, and experiments to annotate protein interactions and predict deleterious variants.

Systematic drug profiling across BAF complex perturbations reveals distinct dependencies

This study systematically profiles drug responses in BAF complex perturbations, revealing subtype-specific vulnerabilities and resistance patterns to genotoxic and cytotoxic compounds.

Systematic discovery of protein interaction interfaces using AlphaFold and experimental validation

The paper evaluates AlphaFold-Multimer for predicting protein interaction interfaces using short linear motifs and validates some predictions experimentally.