Chop Yan Lee

Variant characterization in the intrinsically disordered human proteome

The paper improves variant effect prediction in intrinsically disordered regions by combining sequence analysis, AlphaFold, and experiments to annotate protein interactions and predict deleterious variants.

Systematic discovery of protein interaction interfaces using AlphaFold and experimental validation

The paper evaluates AlphaFold-Multimer for predicting protein interaction interfaces using short linear motifs and validates some predictions experimentally.

An extended Tudor domain within Vreteno interconnects Gtsf1L and Ago3 for piRNA biogenesis in Bombyx mori

This study identifies a novel interaction between BmGtsf1L and BmVreteno's eTudor domain that facilitates piRNA biogenesis in Bombyx mori by connecting piRNA-loaded BmAgo3 and Gtsf1L.