Author

Kōsuke Kikuchi

Institute of Science TokyoORCID 0000-0002-2998-9049Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Takafumi UenoiD· 3 shared Koki DATE· 2 shared Hideki TaguchiiD· 1 shared Hironari KamikuboiD· 1 shared Junko Tanaka· 1 shared Keiichi Okisawa· 1 shared Ririko Kobayashi· 1 shared Satoru TsugawaiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersBiophysics

Takafumi UenoORCID

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3 papers

Recent·Most cited

Assembly-pathway regulation dictates pH-responsive actuation in the R-body protein machinery

Koki DATE, Kōsuke Kikuchi, Tatsuya Niwa, Hironari Kamikubo, Sota Masumura, Thuc Toan Pham, Keiichi Okisawa, Hideki Taguchi, Takafumi Ueno

This study identifies that assembly-pathway regulation, not just major components, dictates pH-responsive actuation in R-bodies by forming the ordered lamellar architecture required for function.

Biomacromolecules · Sep 18, 2026Peer-reviewedBiophysics

In-Cell Protein Crystallization via a Locally Flexible 24-mer Assembly Precursor

Satoshi Abe, Junko Tanaka, Kōsuke Kikuchi, Tadaomi Furuta, Yuta Aizawa, Yoshikazu Tanaka, Takeshi Yokoyama, Shuji Kanamaru, Ririko Kobayashi, Takafumi Ueno

This study defines the assembly pathway of CipB, showing that a 24-mer precursor forms and packs into a cubic lattice, with N-terminal flexibility enabling crystallization.

bioRxiv · Aug 28, 2026 · PreprintBiophysics

Deformation Gradient Tensor Model of Roll-Spiral Transformation for Protein Assembly Refractile Body

Satoru Tsugawa, Kōsuke Kikuchi, Koki DATE, Tomonobu Nonoyama, Zichen Kang, Takafumi Ueno

The paper develops a deformation gradient tensor model to describe the roll-spiral transformation in protein refractile bodies, linking macroscopic morphology with microscopic lattice deformation.

bioRxiv · May 30, 2026 · PreprintBiophysics