Author

Megan Alexandria Brennan

Pennsylvania State UniversityORCID 0000-0002-3001-947XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:Drosophila· 1 Approach:experimental assay· 1

Frequent Co-Authors

Brijesh Singh ChauhaniD· 1 shared Daniela C. ZarnescuiD· 1 shared Justin K. IchidaiD· 1 shared Kendall R. Van Keuren‐JenseniD· 1 shared Peter C. ForstmeieriD· 1 shared Rebekah Keating GodfreyiD· 1 shared Rita SattleriD· 1 shared Yifu HaniD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperNeuroscience

Brijesh Singh ChauhanORCID

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1 paper

Recent·Most cited

NeuroscienceActa Neuropathologica CommunicationsPeer-reviewedOct 26, 2026

C9orf72-associated G4C2 hexanucleotide repeat expression in Drosophila mushroom bodies causes age dependent TDP-43 pathology and dementia relevant phenotypes mediated in part by the glypican Dlp/GPC6

Brijesh Singh Chauhan, Megan Alexandria Brennan, Peter C. Forstmeier…·Daniela C. Zarnescu

This study shows that expressing G4C2 repeats in Drosophila mushroom bodies causes age-dependent TDP-43 pathology and dementia-like phenotypes, with Dlp/GPC6 playing a role in synaptic loss.

DOI 10.1186/s40478-026-02471-z

Drosophilaexperimental assay

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