Brijesh Singh Chauhan

C9orf72-associated G4C2 hexanucleotide repeat expression in Drosophila mushroom bodies causes age dependent TDP-43 pathology and dementia relevant phenotypes mediated in part by the glypican Dlp/GPC6

This study shows that expressing G4C2 repeats in Drosophila mushroom bodies causes age-dependent TDP-43 pathology and dementia-like phenotypes, with Dlp/GPC6 playing a role in synaptic loss.

UPLC-ESI-MS based lipidomics revealed novel biomarkers in insulin receptor knockdown induced type 2 diabetes model of Drosophila

The paper uses lipidomics to identify novel biomarkers for T2D in a Drosophila model by analyzing lipid profiles and statistical patterns.

Modelling dementia in Drosophila uncovers shared and specific targets of TDP-43 proteinopathy across ALS and FTD relevant circuits

This study uses a Drosophila model to investigate TDP-43 proteinopathy in ALS and FTD, identifying shared and circuit-specific molecular targets.

Identification of differentially expressed novel tau associated proteins in transgenic AD model of Drosophila - a proteomic and in silico Approach

The paper identifies six novel tau-associated proteins in a Drosophila AD model using proteomic and in silico methods and explores their potential roles in AD pathophysiology.