Cancer BiologybioRxivPreprint
Myeloma and therapy reshape the bone marrow niche to durably constrain immune reconstitution and vaccine responsiveness
Aishwarya Chander, Samir Rachid Zaim, Mebdh A. Dillon…·Melinda L. Angus-Hill
This study shows how multiple myeloma and its treatment alter the bone marrow niche, impairing immune reconstitution and vaccine responses, with mRNA vaccines showing better efficacy than influenza vaccines.
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