Emma Lo Kuan

Type I Interferon-Driven Monocyte Dysregulation and MAS-associated CD8+ T cells During Macrophage Activation Syndrome

The paper identifies a type I IFN-driven monocyte dysregulation and a MAS-associated CD8+ T cell population in macrophage activation syndrome using bulk and single-cell RNA sequencing.

Myeloma and therapy reshape the bone marrow niche to durably constrain immune reconstitution and vaccine responsiveness

This study shows how multiple myeloma and its treatment alter the bone marrow niche, impairing immune reconstitution and vaccine responses, with mRNA vaccines showing better efficacy than influenza vaccines.

Dissecting type I and II interferon impacts on human immune cells in disease by a cell type-specific interferon response atlas

The paper creates a cell-type-specific IFN response atlas to distinguish IFN-I and IFN-II activities in human immune cells across diseases.

Longitudinal Multi-omic Immune Profiling Reveals Age-Related Immune Cell Dynamics in Healthy Adults

This study uses multi-omic profiling to analyze immune cell dynamics in healthy adults over time, finding age-related transcriptional changes in T cells and impaired memory B cell responses in older adults.

Systemic inflammation and lymphocyte activation precede rheumatoid arthritis

The paper identifies immune alterations preceding rheumatoid arthritis onset and provides tools for dataset exploration.