Julian Reading

Deconvolution of the mechanisms of T cell drug response in multiple myeloma induction therapy

This study investigates the molecular effects of RVd therapy on T cells using TEA-seq, revealing how individual and sequential drug administration impacts T cell function and states.

Multi-omic profiling of human antibody-secreting cells reveals diverse subsets sustain durable humoral immunity

The paper identifies diverse human antibody-secreting cell subsets using multi-omic methods and shows their distinct functional and spatial characteristics.

Myeloma and therapy reshape the bone marrow niche to durably constrain immune reconstitution and vaccine responsiveness

This study shows how multiple myeloma and its treatment alter the bone marrow niche, impairing immune reconstitution and vaccine responses, with mRNA vaccines showing better efficacy than influenza vaccines.

Dissecting type I and II interferon impacts on human immune cells in disease by a cell type-specific interferon response atlas

The paper creates a cell-type-specific IFN response atlas to distinguish IFN-I and IFN-II activities in human immune cells across diseases.

Longitudinal Multi-omic Immune Profiling Reveals Age-Related Immune Cell Dynamics in Healthy Adults

This study uses multi-omic profiling to analyze immune cell dynamics in healthy adults over time, finding age-related transcriptional changes in T cells and impaired memory B cell responses in older adults.

Systemic inflammation and lymphocyte activation precede rheumatoid arthritis

The paper identifies immune alterations preceding rheumatoid arthritis onset and provides tools for dataset exploration.

Multi-lineage transcriptional and cell communication signatures define evolving personalized mechanisms that initiate and perpetuate rheumatoid arthritis

The paper identifies shared transcriptional and cell communication signatures in RA patients and at-risk individuals, showing how multiple pathogenic mechanisms contribute to disease initiation and progression.

CryoSCAPE: Scalable Immune Profiling Using Cryopreserved Whole Blood for Multi-omic Single Cell and Functional Assays

CryoSCAPE enables scalable immune profiling using cryopreserved whole blood for multi-omic single cell and functional assays, demonstrating compatibility with high-throughput RNA sequencing and functional testing.

MOCHA: Advanced statistical modeling of scATAC-seq data enables functional genomic inference in large human disease cohorts

MOCHA improves scATAC-seq analysis by addressing technical and biological challenges, enabling better gene regulatory insights in human disease.