This study shows how multiple myeloma and its treatment alter the bone marrow niche, impairing immune reconstitution and vaccine responses, with mRNA vaccines showing better efficacy than influenza vaccines.

bioRxiv · Apr 9, 2026 · PreprintCancer Biology

Dissecting type I and II interferon impacts on human immune cells in disease by a cell type-specific interferon response atlas

Nicholas Moss, Catalina Sakai, N Kaul, Lucas T. Graybuck, Samir Rachid Zaim, Melinda L. Angus-Hill, Yudong D. He, Erik D. Layton, Paige L. Bouvatte, Peter J. Wittig, Christian M. LaFrance, Tao Peng, Marla C. Glass, Upaasana Krishnan, Aishwarya Chander, , Emma Lo Kuan

The paper creates a cell-type-specific IFN response atlas to distinguish IFN-I and IFN-II activities in human immune cells across diseases.

bioRxiv · Dec 5, 2025 · PreprintImmunology

Longitudinal Multi-omic Immune Profiling Reveals Age-Related Immune Cell Dynamics in Healthy Adults

Qiuyu Gong, Mehul Sharma, Marla C. Glass, Emma Lo Kuan, Aishwarya Chander, Mansi Singh, Lucas T. Graybuck, Zachary Thomson, Christian M. LaFrance, Samir Rachid Zaim, Tao Peng, Lauren Y. Okada, Palak C. Genge, Katherine E. Henderson, Elisabeth M. Dornisch, , Claire E. Gustafson

This study uses multi-omic profiling to analyze immune cell dynamics in healthy adults over time, finding age-related transcriptional changes in T cells and impaired memory B cell responses in older adults.

Nature · Oct 29, 2025Peer-reviewedImmunology

Systemic inflammation and lymphocyte activation precede rheumatoid arthritis

Ziyuan He, Marla C. Glass, Pravina Venkatesan, Marie L. Feser, Leander Lazaro, Lauren Y. Okada, Nhung T. T. Tran, Yudong D. He, Samir Rachid Zaim, Christy Bennett, Padmapriyadarshini Ravisankar, Elisabeth M. Dornisch, Alexandra Ferrannini, Najeeb A. Arishi, Ashley G. Asamoah, , Mark A. K. Gillespie

The paper identifies immune alterations preceding rheumatoid arthritis onset and provides tools for dataset exploration.

Science Translational Medicine · Sep 24, 2025Peer-reviewedImmunology