Xiaojing Li

This paper introduces a direct RNA sequencing workflow to profile tRNA abundance and modifications in mouse liver, identifying key modification sites and isotype-specific patterns.

This paper identifies metabolic reprogramming driven by thyroid-stimulating antibodies as a key mechanism in thyroid eye disease, showing lactate promotes adipogenesis through histone lactylation.

This study develops YC3, a TSHR-targeting aptamer that inhibits TSHR signaling and treats Graves' ophthalmopathy by binding to a novel allosteric site.

This paper develops a ratio-based framework using Quartet reference materials to integrate long- and short-read RNA-seq data, showing hybrid-seq achieves the highest quantification accuracy.

This paper identifies a common genetic factor across schizophrenia, bipolar disorder, and major depressive disorder using a trans-diagnostic, top-down approach, and links it to ZNF391 expression patterns in the brain that correlate with cognitive and neuroimaging traits.