Mao Ye

This paper identifies metabolic reprogramming driven by thyroid-stimulating antibodies as a key mechanism in thyroid eye disease, showing lactate promotes adipogenesis through histone lactylation.

The paper shows that cardiac defects in ATF4 knockout mice result from unintended Rps19bp1 downregulation due to transcriptional readthrough, not loss of ATF4 function.

This study develops YC3, a TSHR-targeting aptamer that inhibits TSHR signaling and treats Graves' ophthalmopathy by binding to a novel allosteric site.

The paper shows that CGRPPBel neurons encode opposing valence through frequency-dependent differential release of glutamate and neuropeptides in response to aversive and appetitive stimuli.

The paper develops two genetically encoded tools to monitor and silence neuropeptide release in vivo, revealing neuropeptides, not glutamate, as the primary transmitter in Pavlovian threat learning.

The paper identifies a circRNA-miRNA-mRNA axis in chicken myoblasts, showing circPLXNA2 promotes proliferation and inhibits apoptosis by modulating MDM4 expression.

The paper identifies unified neural pathways that gate affective pain and multisensory innate threat signals to the amygdala, revealing their role in aversive perception.

This study identifies a novel neural circuit involving PBLOprm1 neurons that regulates breathing, pain, and anxiety by linking limbic signals to respiratory control.