Author

Jan C. Verburg

Institute of Genetics and CancerORCID 0000-0002-3012-3015Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:whole-genome sequencing· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:mouse· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Ailith EwingiD· 2 shared Christine FeigiD· 2 shared Claudia Arnedo-PaciD· 2 shared Colin A M SempleiD· 2 shared Craig J. AndersoniD· 2 shared Duncan T. OdomiD· 2 shared Elissavet KentepozidouiD· 2 shared Erika López‐ArribillagaiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

Ailith EwingORCID

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Author profile →

2 papers

Recent·Most cited

Genetic background sets the trajectory of cancer evolution

Sarah J. Aitken, Frances Connor, Christine Feig, Tim F. Rayner, Margus Lukk, Juliet Luft, Stuart Aitken, Claudia Arnedo-Pac, J.V. Hayes, Michael D. Nicholson, Ailith Ewing, Vasavi Sundaram, Jan C. Verburg, John Connelly, Craig J. Anderson, , Duncan T. Odom

This study shows that genetic background and environmental factors determine the trajectory of cancer evolution in mice, with distinct mutational paths despite similar final tumor states.

Nature · Jul 22, 2026Peer-reviewedGenomics

Strand-resolved mutagenicity of DNA damage and repair

Craig J. Anderson, Lana Talmane, Juliet Luft, John C. Connelly, Michael D. Nicholson, Jan C. Verburg, Oriol Pich, Susan E. Campbell, Marco Giaisi, Pei‐Chi Wei, Vasavi Sundaram, Frances Connor, Paul Adrian Ginno, Takayo Sasaki, David M. Gilbert, , Martin S. Taylor

The paper investigates how strand-asymmetric processes like replication and transcription influence DNA damage, repair, and mutagenesis, revealing mechanisms that shape cancer genome evolution.

Nature · Jun 12, 2024Peer-reviewedGenomics