Author

Tim F. Rayner

University of CambridgeORCID 0000-0002-6992-5592Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Christine FeigiD· 3 shared Duncan T. OdomiD· 3 shared Frances ConnoriD· 3 shared Ailith EwingiD· 2 shared Aisling M. RedmondiD· 2 shared Claudia Arnedo-PaciD· 2 shared Colin A M SempleiD· 2 shared Craig J. AndersoniD· 2 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenomics

Christine FeigORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Genetic background sets the trajectory of cancer evolution

Sarah J. Aitken, Frances Connor, Christine Feig, Tim F. Rayner, Margus Lukk, Juliet Luft, Stuart Aitken, Claudia Arnedo-Pac, J.V. Hayes, Michael D. Nicholson, Ailith Ewing, Vasavi Sundaram, Jan C. Verburg, John Connelly, Craig J. Anderson, , Duncan T. Odom

This study shows that genetic background and environmental factors determine the trajectory of cancer evolution in mice, with distinct mutational paths despite similar final tumor states.

Nature · Jul 22, 2026Peer-reviewedGenomics

Strand-resolved mutagenicity of DNA damage and repair

Craig J. Anderson, Lana Talmane, Juliet Luft, John C. Connelly, Michael D. Nicholson, Jan C. Verburg, Oriol Pich, Susan E. Campbell, Marco Giaisi, Pei‐Chi Wei, Vasavi Sundaram, Frances Connor, Paul Adrian Ginno, Takayo Sasaki, David M. Gilbert, , Martin S. Taylor

The paper investigates how strand-asymmetric processes like replication and transcription influence DNA damage, repair, and mutagenesis, revealing mechanisms that shape cancer genome evolution.

Nature · Jun 12, 2024Peer-reviewedGenomics

Interplay of cis and trans mechanisms driving transcription factor binding and gene expression evolution

Emily S. W. Wong, Bianca M. Schmitt, Anastasiya Kazachenka, David Thybert, Aisling M. Redmond, Frances Connor, Tim F. Rayner, Christine Feig, Anne C. Ferguson‐Smith, John C. Marioni, Duncan T. Odom, Paul Flicek

The paper investigates cis and trans mechanisms influencing transcription factor binding and gene expression evolution in mice by analyzing allele-specific occupancy in crosses of two inbred strains.

Nature Communications · Oct 17, 2017Peer-reviewedGenomics