Eberhard Hildt

pyKinaXe: a fast and robust turnkey kinase activity profiler

pyKinaXe is a Python package that automates the analysis of PamChip data, offering faster and more efficient kinase activity profiling compared to existing tools.

Inhibition of Nrf1 activity is a relevant for the HCV-dependent dysregulation of host lipid metabolism

This study shows that HCV reduces Nrf1 proteoforms and inhibits their nuclear translocation, leading to increased cholesterol and lipid droplets, which support HCV replication and pathogenesis.

Reversal effects of Isochlorogenic acid A on HBV-induced transcriptional dysregulation and apoptotic signaling

This study investigates how ICAA affects HBV-induced gene expression and apoptotic signaling in HepAD38 cells, finding it reverses transcriptional dysregulation and promotes apoptosis.

Late stages of the Zika virus life cycle are impaired by a selective TRPML2 agonist

This study shows that the TRPML2 agonist ML2-SA1 inhibits late stages of Zika virus replication by affecting genome replication and intracellular cholesterol distribution.