MicrobiologybioRxivPreprint
Inhibition of Nrf1 activity is a relevant for the HCV-dependent dysregulation of host lipid metabolism
Olga Szostek, Patrycja Schorsch, Daniela Bender, Eberhard Hildt
This study shows that HCV reduces Nrf1 proteoforms and inhibits their nuclear translocation, leading to increased cholesterol and lipid droplets, which support HCV replication and pathogenesis.
DOI 10.64898/2026.05.29.728748