NeurosciencebioRxivPreprint
Mechanical load conditions the spectrin network to `run-on' proteolysis and promotes early onset neurodegeneration
Nawaphat Malaiwong, Anne-Kristin Dahse, Li-Chun Lin…·Michael Krieg
This study shows that age-related loss of proprioception in C. elegans is linked to spectrin cytoskeleton degradation due to mechanical stress and calcium-sensitive proteolysis, which can be mitigated by chaperone expression.
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