Nawaphat Malaiwong

Functions and trafficking mechanisms of RIC-8 in C. elegans and mammalian cilia

This study identifies ciliary trafficking mechanisms and functions of RIC-8 in C. elegans and mammalian cilia, showing its role in chemosensory responses and ciliogenesis.

FLInt 2.0: Robust and customizable single shot integration in C. elegans

FLInt 2.0 improves transgene integration in C. elegans by reducing false positives through targeted Cas9 cutting and fluorescence preservation during repair events.

An ancient monoaminergic signaling system coordinates contractility in a nerveless sponge

This study identifies an ancient monoaminergic system in sponges that coordinates contractility through tryptamine signaling, predating neurons.

Nuclear receptor-neurotransmitter coupling links behavior to metabolic state

This study identifies a mechanism in C. elegans where lipidated neurohormones couple neurotransmitter signaling with lipid metabolism to regulate behavior.

Mechanical load conditions the spectrin network to `run-on' proteolysis and promotes early onset neurodegeneration

This study shows that age-related loss of proprioception in C. elegans is linked to spectrin cytoskeleton degradation due to mechanical stress and calcium-sensitive proteolysis, which can be mitigated by chaperone expression.

FLInt: Single Shot Safe Harbor Transgene Integration via Fluorescent Landmark Interference

FLInt enables efficient and safe transgene integration in C. elegans using fluorescent marker loci and CRISPR/Cas9, allowing easy screening through fluorescence interference.

Mechanical Stretch Inhibition SensitizesProprioceptors to Compressive Stresses

The paper investigates proprioception in C. elegans, finding that proprioceptors respond to compressive stresses and encode body posture through mechanosensitive ion channels.