Michael Krieg

This study shows how Tau condensates age into elastic networks with inhomogeneous polymerization and seed formation, providing mechanistic insight into their transition to pathological aggregates.

This study shows that touch receptors in C. elegans detect surface traction, influencing proprioception and locomotion through MEC-4 channel activity and friction force.

The paper introduces improved bioluminescent calcium sensors and opsin variants for non-invasive imaging and synaptic transmission in C. elegans.

The paper shows periodic obstacles regulate membrane tension propagation in neurons, enabling localized mechanotransduction by restricting tension spread.

This paper develops a Fourier light field microscope with deep learning for fast, high-resolution bioluminescence imaging, demonstrating its use in 3D calcium imaging and cell dynamics analysis.

The paper shows sensory experience influences dendritic structure and behavior in C. elegans PVD neurons through degenerin channels, with structural and behavioral changes being functionally independent.

This study shows that age-related loss of proprioception in C. elegans is linked to spectrin cytoskeleton degradation due to mechanical stress and calcium-sensitive proteolysis, which can be mitigated by chaperone expression.

The paper shows how a single neuron in C. elegans integrates opposing spatial cues to guide decision-making during avoidance behavior.

FLInt enables efficient and safe transgene integration in C. elegans using fluorescent marker loci and CRISPR/Cas9, allowing easy screening through fluorescence interference.

This study shows that magnetic nano-pulling induces axonal cytoskeleton remodeling, enhancing outgrowth and synapse maturation through microtubule density increase and local translation promotion.

This study identifies sexual dimorphism in the mechanosensory circuit of C. elegans, showing differences in neuronal wiring and molecular mechanisms between sexes.

The paper develops a synthetic photon-assisted synaptic transmission system to restore communication in neurons and demonstrates its ability to rescue behavioral deficits in C. elegans.

The paper investigates proprioception in C. elegans, finding that proprioceptors respond to compressive stresses and encode body posture through mechanosensitive ion channels.

The paper shows that Tmc channels in Drosophila proprioceptors are required for direction-selective activity, with dendrite curvature triggering mechanosensory responses during locomotion.