NeuroscienceProceedings of the National Academy of SciencesPeer-reviewed
Amyloid Beta Glycation Induces Neuronal Mitochondrial Dysfunction and Alzheimers Pathogenesis via VDAC1-Dependent mtDNA Efflux
Firoz Akhter, Asma Akhter, Xiongwei Zhu…·Donghui Zhu
This paper shows that glycated amyloid-beta causes mitochondrial dysfunction and Alzheimer's pathology by triggering the cGAS-STING pathway via VDAC1-dependent mtDNA release.