Fan Gao

This study shows that p53 activation via DNA damage response causes aberrant neuronal activity in neurodegenerative diseases, and inhibiting p53 reduces this activity in a human iPSC model.

This study uses Stereo-seq to analyze spatial transcriptomics in 5xFAD mice, linking neuronal transcriptomic changes to amyloid pathology at single-cell resolution.

The paper identifies androgen receptor-mediated regulation of sexually dimorphic gene expression in the mouse kidney and finds limited conservation in human kidney.

The paper investigates the dynamic interaction between Opa/ZIC and Oc/OTX in regulating head development, finding that Opa and Oc compete for gene regulation in different developmental stages.

The paper constructs a gene regulatory network (GRN) for alveologenesis in a mouse model of BPD, revealing how IGF1 signaling regulates lung development and identifies potential therapeutic targets.

The paper develops snATAK for preprocessing single-nucleus chromatin accessibility data and evaluates tradeoffs between multimodal assays.

The paper presents a whole-animal transcriptomic cell atlas of Clytia hemisphaerica using multiplexed scRNA-seq to study cell type plasticity under starvation.

The paper identifies Atp13a5 as a specific marker for CNS pericytes in mice and develops a transgenic model to study their biology.

The paper presents a modular and efficient workflow for single-cell RNA-seq pre-processing using kallisto and bustools, demonstrating its flexibility for RNA velocity analyses.

The paper identifies potassium-driven cerebrospinal fluid (CSF) clearance through the choroid plexus during a critical neurodevelopmental phase in mice, showing its role in preventing hydrocephalus.

The paper shows that Odd-paired (Opa) acts as a late-acting pioneer factor that coordinates with Zelda to regulate gene expression in early Drosophila embryos.

The paper identifies common molecular signatures of cerebrovascular injury in traumatic brain injury and aging using single-cell RNA-seq data from mouse models.

This study shows that NRGN modulates synaptic plasticity by regulating the phosphoproteome, linking it to schizophrenia and autism-related pathways.

Neutools provides web-based bioinformatics tools for neurogenomic data analysis and visualization, enabling researchers to explore gene overlaps, expression patterns, and GWAS variants.