Triantafyllos Stylianopoulos

This study shows that blocking the endothelin receptor pathway enhances T cell and CAR T cell therapies in cancer models by improving antitumour responses and durable immunity.

The paper develops a physiologically based pharmacokinetic model to simulate CAR-T cell dynamics in solid tumors, showing vascular normalization improves efficacy and reduces required CAR-T doses.

This paper develops a mathematical model to optimize the combined use of mechanotherapy and ultrasound sonopermeation for enhancing nano-immunotherapy in solid tumors.