Preventing surgery induced immune suppression and metastases by inhibiting PI3K-gamma signalling in Myeloid-Derived Suppressor Cells.
Leonard Angka, Gayashan Tennakoon, David P. Cook, Andre B. Martel, Marisa Market, Christiano Tanese de Souza, Emma Cummins, Ismael J. Samudio, Natasha K. Kekre, Michele Ardolino, Barbara C. Vanderhyden, Michael A. Kennedy, Rebecca C. Auer
The paper identifies PI3K-gamma signaling as a key pathway in surgery-induced MDSCs that suppresses NK cells and promotes metastases, showing that targeting this pathway can reduce postoperative metastases.
Journal for ImmunoTherapy of Cancer · Jan 1, 2026Peer-reviewedImmunology