Peter M. Kasson

Tuning nanoscale lipid clustering controls influenza viral binding

This study shows that nanoscale lipid clustering enhances influenza viral binding by increasing local glycosphingolipid concentration, with binding avidity dependent on the spatiotemporal scales of this clustering.

Unmasking complex kinetics in viral entry by inferring hypoexponential models

This study introduces hypoexponential analysis to estimate heterogeneous kinetic processes in viral entry, showing ACE2 reduces rate-limiting steps but not their rates in SARS-CoV-2 entry.

ProGuide: a flexible framework for modeling global conformational rearrangements in proteins using DEER-derived distance restraints

ProGuide generates structural models of protein conformations using DEER-derived distance restraints, revealing novel conformational states in the angiotensin II type 1 receptor.

Caveolin assemblies displace one bilayer leaflet to organize and bend membranes

This paper investigates how the CAV1-8S caveolin complex interacts with lipid membranes through a novel leaflet replacement mechanism, revealing its role in membrane curvature and organization.

Influenza viral infection at the plasma membrane is restricted by lipid composition

This study shows that influenza virus fusion at the plasma membrane is less efficient than through endosomes, primarily due to differences in membrane composition and order.

A Collagen Triple Helix without the Super Helical Twist

The paper designs collagenous assemblies using a peptide self-assembly system and solves their structure with cryo-EM, revealing a non-twisting triple helix conformation that differs from the canonical right-handed triple helix.

gmxapi: a Gromacs-native Python interface for molecular dynamics with ensemble and plugin support

gmxapi provides a Python interface for GROMACS molecular dynamics simulations, enabling custom plugins, ensemble simulations, and high-level data-flow algorithms.

Refinement of highly flexible protein structures using simulation-guided spectroscopy

This paper develops an information-theoretic method to guide spectroscopic experiments for refining flexible protein structures, showing improved performance over standard approaches.