Bing Han

OpenGerminal: an open-source implementation of the Germinal antibody design pipeline

OpenGerminal replaces PyRosetta with open-source tools and benchmarks IgLM versus AbLang1 in the Germinal antibody design pipeline, achieving higher cofolding pass rates with equivalent structural confidence.

Structural basis of caveolin-driven membrane bending

This study identifies how caveolin-1's hydrophobic residue patterning drives membrane bending through structural and computational analyses.

Palmitoylated caveolin-1 enables endosome sorting of complex sphingolipids

The paper shows that palmitoylated caveolin-1 facilitates endosome sorting of complex sphingolipids to the plasma membrane, independent of caveolae.

Caveolin assemblies displace one bilayer leaflet to organize and bend membranes

This paper investigates how the CAV1-8S caveolin complex interacts with lipid membranes through a novel leaflet replacement mechanism, revealing its role in membrane curvature and organization.