Enrique Sanz‐García

The paper uses whole-genome and transcriptome sequencing to identify two consensus cancer subtypes in biliary tract cancer, revealing divergent molecular landscapes that better explain tumor heterogeneity than anatomical classification.

This study shows that hematopoietic Tet2 inactivation improves immune checkpoint blockade response in mice and is associated with better clinical outcomes in melanoma patients with TET2-driven clonal hematopoiesis.

This study investigates the dual role of EphA4 in T regulatory cells and tumor-associated macrophages during HNSCC progression, showing pro-tumoral and anti-tumoral effects respectively.