Andy G.X. Zeng

This study identifies locus-specific transposable elements driving VEXAS syndrome pathophysiology by regulating myeloid commitment in UBA1-mutant hematopoietic stem cells.

This study identifies that HIF-1 activation by PIM1 in JAK2V617F-MPNs drives non-canonical transcription complex formation and disease progression.

This study shows that hematopoietic Tet2 inactivation improves immune checkpoint blockade response in mice and is associated with better clinical outcomes in melanoma patients with TET2-driven clonal hematopoiesis.

The paper identifies ATP2B1 as a marker for human LT-HSC subpopulations with distinct repopulation and self-renewal capacities across ontogeny.

This study identifies stress granules as critical for AML stem cell survival and stress adaptation, revealing their role in gene regulation and potential as therapeutic targets.