Jessie Huang

This study identifies PCBP1's role in regulating AARS2 alternative splicing and its impact on heart development and congenital cardiomyopathy.

This study shows that PRC2 maintains AT2 cell fate in the adult lung by preventing transitions to ABI and basal-like states, both in vitro and in vivo.

This study shows that cell packing order in human lung alveolospheres increases with nucleus-to-cell size ratio, resembling a gas-to-liquid transition, and may regulate organ development and maturation.

This study uses human stem cell-derived alveolar type 2 cells to model SARS-CoV-2 infection, revealing rapid inflammatory responses and drug efficacy against the virus.

Human iPSC-derived alveolar type II-like and airway epithelial cells adapted to two-dimensional air-liquid interface culture express ACE2 and TMPRSS2 at frequencies comparable to primary lung epithelial controls.

The paper reconstructs signaling and regulatory networks for SARS-CoV-2 infection and identifies potential drug targets by integrating multi-omics data and experimental validation.