Thomas Seidel

The paper quantifies TATS ultrastructural features across eight mammalian species and finds correlations between TATS density, cardiomyocyte size, and physiological parameters like heart rate and lifespan.

This study identifies polyploid cardiomyocytes as disease-specific transcriptional states in the mammalian heart and suggests targeting them for heart failure treatment.

This study identifies PKC-driven T-tubule membrane loss through a PKD-NFκB endocytic pathway in cardiomyocytes, showing impaired contractility and arrhythmia risk.

This study uses single-cell RNA-sequencing and spatial transcriptomics to analyze the spatio-temporal dynamics of the fibrotic niche in cardiac repair after ventricular injury in adult mice, identifying key cell interactions and regulatory mechanisms.