Jerzy Kotlinowski

Differential effects of fenofibrate and fenofibric acid on the regulation of liver endothelial permeability

This paper investigates how fenofibrate and its metabolite fenofibric acid affect liver endothelial permeability, finding fenofibrate reduces fenestration and mechanical properties while fenofibric acid does not.

Offsetting ROS-mediated arrest of endothelial fenestration dynamics permits long-term optical super-resolution- and AFM-imaging

The paper identifies ROS as a cause of fenestration arrest in LSECs during imaging and proposes a strategy to preserve dynamics for long-term super-resolution and AFM imaging.

Hepatic MCPIP1 protein levels are reduced in NAFLD patients and are predominantly expressed in cholangiocytes and liver endothelium

This study shows that MCPIP1 protein levels are lower in NAFLD patients' livers compared to controls, but not in PBMCs, and correlate with hepatic steatosis.

Role of Mcpip1 in obesity-induced hepatic steatosis as determined by myeloid and liver-specific conditional knockouts.

This study investigates the role of Mcpip1 in obesity-induced hepatic steatosis using myeloid and liver-specific conditional knockouts, finding that myeloid depletion leads to systemic inflammation and metabolic dysregulation, while liver-specific depletion has less impact.