Karolina Szafranska

This study examines how polypharmacy affects liver sinusoidal endothelial cells, showing drug- and concentration-dependent changes in fenestrations and endocytosis.

This study develops a 2D monoculture method to maintain primary mouse LSEC viability and endocytic function for 10 days, enabling siRNA knockdown of Mrc1.

This paper investigates how fenofibrate and its metabolite fenofibric acid affect liver endothelial permeability, finding fenofibrate reduces fenestration and mechanical properties while fenofibric acid does not.

The paper identifies ROS as a cause of fenestration arrest in LSECs during imaging and proposes a strategy to preserve dynamics for long-term super-resolution and AFM imaging.

This study shows that hydrogen peroxide damages liver sinusoidal endothelial cells, reducing their scavenging function and causing structural changes, which can be mitigated by N-acetyl-cysteine but not glutathione.