B cell receptor silencing reveals the origin of high-grade B cell lymphomas with MYC and BCL2 rearrangements
Gabriele Varano, Silvia Lonardi, Paola Sindaco, Ilaria Pietrini, Gaia Morello, Piera Balzarini, Filippo Vit, Hadas Neuman, Giorgio Bertolazzi, Silvia Brambillasca, Nicara C. Parr, Marco Chiarini, Silvia Bellesi, Elena Maiolo, Sabrina Giampaolo, , Stefano S Casola
This paper shows that high-grade B cell lymphomas with MYC and BCL2 rearrangements originate from BCR-silenced follicular lymphoma cells that acquire IGL::MYC translocations, leading to resistance to CD79B-targeting therapy.
Blood Cancer Discovery · May 22, 2025Peer-reviewedCancer Biology