Author

David R Piwnica-Worms

The University of Texas MD Anderson Cancer CenterORCID 0000-0002-2120-7217Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Seth T. GammoniD· 3 shared Ajlan Al ZakiiD· 1 shared An Q DinhiD· 1 shared Angela Davidian· 1 shared Anja KarlstaedtiD· 1 shared Arianna Di NapoliiD· 1 shared Benjamin Aaron GarciaiD· 1 shared Benjamin D. Gould· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCancer Biology

Seth T. GammonORCID

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3 papers

Recent·Most cited

Targeted Molecular MRI of Colorectal Cancer by Antibody Functionalized Hyperpolarized Silicon Particles

Nicholas Whiting, Jingzhe Hu, Shivanand Pudakalakatti, Caitlin V. McCowan, Saleh M. Ramezani, Jennifer Sarah Davis, Niki Marie Zacharias, Brian J. Engel, Julie X. Liu, Klaramari Gellci, Hyeonglim Seo, Devin Brown, José S. Enriquez, David G. Menter, Steven W. Millward, , Pratip K. Bhattacharya

This study develops hyperpolarized silicon particles functionalized with MUC1 antibody for targeted molecular MRI of colorectal cancer, showing active tumor targeting in vivo.

bioRxiv · May 6, 2025 · PreprintCancer Biology

Statins inhibit onco-dimerization of the 4Ig isoform of B7-H3

Margie Nicole Sutton, Sarah E. Glazer, Ajlan Al Zaki, Arianna Di Napoli, Ping Yang, Priya Bhosale, Jinsong Liu, Seth T. Gammon, David R Piwnica-Worms

This study identifies statins as inhibitors of 4Ig-B7-H3 dimerization, linking their anti-cancer effects to immune checkpoint disruption in B7-H3-expressing tumors.

bioRxiv · Dec 18, 2024 · PreprintCancer Biology

ATP-dependent citrate lyase Drives Left Ventricular Dysfunction by Metabolic Remodeling of the Heart

Shijie Liu, Seth T. Gammon, Lin Tan, Yaqi Gao, Kyoungmin Kim, Ian Williamson, Janet Pham, Angela Davidian, Radhika Khanna, Benjamin D. Gould, Rebecca Salazar, Heidi Vitrac, An Q Dinh, Evan C. Lien, Francisca N. de Luna Vitorino, , Anja Karlstaedt

This study shows that ACL loss in the heart increases glucose oxidation and reduces citrate efflux, leading to metabolic remodeling and cardiac dysfunction.

bioRxiv · Jun 21, 2024 · PreprintMolecular Biology