Chizu Tanikawa

TET2-mutant clonal hematopoiesis prevents T-cell exhaustion and suppresses cancer metastasis

The paper shows TET2-mutant clonal hematopoiesis reduces cancer metastasis by preventing T-cell exhaustion through DNA methylation changes.

Genotype imputation accuracy and the quality metrics of the minor ancestry in multi-ancestry reference panels

The paper evaluates genotype imputation accuracy in multi-ancestry reference panels and finds that the Rsq metric overestimates dosage r2 due to systematic bias in imputation quality.

Large scale genome-wide association study in a Japanese population identified 45 novel susceptibility loci for 22 diseases

A large-scale GWAS in 212,453 Japanese individuals identified 45 novel susceptibility loci for 22 diseases, highlighting the importance of non-European population studies.

Genetic variants of calcium and vitamin D metabolism in kidney stone disease

This study identifies 20 genetic loci associated with kidney stone disease, including novel variants in CYP24A1 and DGKD, which influence vitamin D metabolism and calcium-sensing receptor signaling.

GWAS identifies nine nephrolithiasis susceptibility loci related with metabolic and crystallization pathways

This study identifies 14 nephrolithiasis susceptibility loci in the Japanese population, including 9 novel loci, and links them to metabolic and crystallization pathways.